期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 250, 期 -, 页码 146-149出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2017.07.061
关键词
Pacemaker; Defibrillator; Lead extraction; Endocarditis; Infection; Vegetation
Background: Despite the improvements in transvenous lead extraction (TLE), patients with cardiac implantable device related infection (CIEDI) have a poor prognosis at long term. We explored the possible role of factors associated with development of CIEDI as predictors of post-TLE survival. Methods: We performed a multi-center prospective observational study in a population of consecutive patients referred for TLE for CIEDI. We adopted a previously developed 10-point scale for CIEDI risk stratification and assessed its performance in predicting post-TLE survival. Results: We enrolled 169 consecutive patients with CIEDI (systemic infection in 48.5% and vegetations in 24.5%). A Shariff score (=>=) 3 was present in 102/169 (60.4%) of the enrolled patients. Complete radiological success of TLE was obtained in 163 patients. Twenty-seven patients (15.9%) died after a mean follow-up of 20.8 +/- 12.0 months. Two factors were independently associated with post-TLE death: a Shariff score >= 3 (HR 10.833, 95% CI 2.544-46.129; p = 0.001) and the presence of vegetations at transesophageal echocardiography (HR 3.324, 95% CI 1.530-7.221; p = 0.002). Conclusions: Risk factors for development of CIEDI are also predictive of post TLE mortality, together with the presence of vegetations. Improvement of our preventive strategies for CIEDI is crucial for enhancing the outcomes of CIED patients overall. (C) 2017 Elsevier B.V. All rights reserved.
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