期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 264, 期 -, 页码 172-178出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2018.03.128
关键词
LDL particles; NMR metabolomics; Cardiovascular disease; Prospective study
资金
- Strategic Action for Research in Health Sciences [CP12/03080, PI15/00071, PI12/02615, PI16/01402, PI14/00874, PI11/00726]
- Valencia Government [PROMETEO/2009/029, ACOMP/2013/039]
- Spanish Ministry of Economy and Competitiveness [SAF2014-52875R]
- Castilla-Leon Government [GRS/279/A/08]
- EU-MASCARA [HEALTH.2011.2.4.2-2]
- Big Data for Better Hearts [IMI2-116074]
- CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn) [CIBER-02-08-2009, CB06/03, CB12/03/30016]
- CIBER de Diabetes y Enfermedades Metabolicas Relacionadas [CIBERDEM CB07/08/0018]
- European Funds for Regional Development (FEDER)
Background: The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study. Methods: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale (R)). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale (R) technique in a representative sample of 1162 adult men and women from Spain. Results: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 +/- 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively. Conclusions: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD. (C) 2018 Elsevier B.V. All rights reserved.
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