期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 266, 期 -, 页码 24-30出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2018.04.083
关键词
Biological markers; Coronary heart disease; Cystathionine; Glutathione
资金
- KG Jebsen Centre for Diabetes Research, University of Bergen, the Department of Heart Disease, Haukeland University Hospital, Bergen
- Western Norway Regional Health Authority
- Foundation to Promote Research into Functional Vitamin B12 Deficiency, Bergen, Norway
- Southeast Center for Integrated Metabolomics Pilot and Feasibility Grant from the National Institutes of Health [U24DK097209]
Background: Cystathionine is a thio-ether and a metabolite formed from homocysteine during transsulfuration. Elevated plasma cystathionine levels are reported in patients with cardiovascular disease; however prospective relationships with acute myocardial infarction (AMI) are unknown. We investigated associations between plasma cystathionine and AMI among patients with suspected and/or verified coronary heart disease (CHD). Methods: Subjects from two independent cohort studies, the Western Norway Coronary Angiography Cohort (WECAC) (3033 patients with stable angina pectoris; 263 events within 4.8 years of median follow-up) and the Norwegian Vitamin Trial (NORVIT) (3670 patients with AMI; 683 events within 3.2 years of median follow-up) were included. Results: In both cohorts, plasma cystathionine was associated with several traditional CHD risk factors (P < 0.001). Comparing the cystathionine quartile 4 to 1, age and gender adjusted hazard ratios (95% confidence intervals) for AMI were 2.08 (1.43-3.03) and 1.41 (1.12-1.76) in WECAC and NORVIT, respectively. Additional adjustment for traditional risk factors slightly attenuated the risk estimates, which were generally stronger in both cohorts among non-smokers, patients with higher age, and lower BMI or PLP status (P-interaction <= 0.04). Risk associations also tended to be stronger in patients not treated with B-vitamins. Additionally, in a subset of 80 WECAC patients, plasma cystathionine associated strongly negatively with glutathione, an important antioxidant and positively with lanthionine, a marker of H2S production (P < 0.001). Conclusions: Plasma cystathionine is associated with increased risk of AMI among patients with either suspected or verified coronary heart disease, and is possibly related to altered redox homeostasis. (C) 2017 The Authors. Published by Elsevier B.V.
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