期刊
GENE
卷 573, 期 2, 页码 310-320出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.07.066
关键词
Kae1; Arginase; Ornithine aminotransferase; rcoA(TUP1)
资金
- Polish Ministry of Science and Higher Education [NN301506438]
- National Science Centre [2012/07/B/NZ2/02037]
- [POIG.02.02.00-14-024/08-00]
The kaeA(KAE1) (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of praline auxotrophic mutations, encodes the orthologue Of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA(TUP1), which encodes the global transcriptional corepressor. (C) 2015 The Authors. Published by Elsevier B.V.
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