期刊
INTERNATIONAL JOURNAL OF CANCER
卷 143, 期 4, 页码 801-812出版社
WILEY
DOI: 10.1002/ijc.31367
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资金
- Direction Generale de la Sante (French Ministry of Health) [GR-IARC-2003-09-12-01]
- European Commission (Directorate General for Health and Consumer Affairs)
- International Agency for Research on Cancer
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer
- Institut Gustave Roussy
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (France)
- Deutsche Krebshilfe
- Deutsches Krebsforschungszentrum
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation
- Stavros Niarchos Foundation
- Hellenic Ministry of Health and Social Solidarity (Greece)
- Italian Association for Research on Cancer
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch Zorg Onderzoek Nederland
- World Cancer Research Fund
- Statistics Netherlands (the Netherlands)
- Health Research Fund, Regional Governments of Andalucya, Asturias, Basque Country, Murcia [6236]
- Instituto de Salud Carlos III, Redes de Investigacion Cooperativa [RD06/0020]
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane (Sweden)
- Cancer Research UK [14136, C570/A16491, C8221/A19170]
- Medical Research Council [1000143, MR/M012190/1]
- Stroke Association
- British Heart Foundation
- Department of Health
- Food Standards Agency
- Wellcome Trust (UK)
- Communautee de Recherche Academique de la region Auvergne Rhone-Alpes
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Medical Research Council [MR/M012190/1] Funding Source: researchfish
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. What's new? Pancreatic cancer (PC) has been associated with alcohol consumption but studies are inconsistent and hampered by low numbers of incident events. Here, the authors studied more than 1000 PC cases and found that baseline and lifetime alcohol intakes were positively related to PC, with stronger risks for beer and spirit than wine intake. Associations were not modulated by smoking habits, underscoring the role of alcohol as a potential carcinogen for PC.
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