期刊
INTERNATIONAL JOURNAL OF CANCER
卷 143, 期 9, 页码 2250-2260出版社
WILEY
DOI: 10.1002/ijc.31611
关键词
mismatch repair; Lynch syndrome; colorectal cancer; physical activity
类别
资金
- National Cancer Institute [UM1 CA167551, U01 CA074778, U01/U24 CA097735, U01/U24 CA074800, U01/U24 CA074783, U01/U24 CA074794, U01/U24 CA074806, U01/U24 CA074799, K07CA160753, R25CA056452, P30CA016672]
- Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute
- Fred Hutchinson Cancer Research Center [N01-CN-67009, N01-PC-35142, HHSN2612013000121]
- Hawaii Department of Health, SEER Program of the National Cancer Institute [N01-PC-67001, N01-PC-35137, HHSN26120100037C]
- California Department of Public Health, SEER Program of the National Cancer Institute [HHSN261201000140C, HHSN261201000035C]
- US State Cancer Registry: AZ
- US State Cancer Registry: CO
- US State Cancer Registry: MN
- US State Cancer Registry: NC
- US State Cancer Registry: NH
- Victorian Cancer Registry, Australia
- Ontario Cancer Registry, Canada
- National Health and Medical Research Council (NHMRC), Australia [APP1074383, APP1073395, APP1125268, APP1117611, APP1023434]
- University of Melbourne Research at Melbourne Accelerator Program (R@MAP) [13947]
- Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute
Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk in people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers (n = 807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self-reported physical activity in three age-periods (20-29, 30-49 and >= 50 years) was summarized as average metabolic equivalent of task hours per week (MET-hr/week) during the age-period of cancer diagnosis or censoring (near-term exposure) and across all age-periods preceding cancer diagnosis or censoring (long-term exposure). Weighted Cox regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for the association between physical activity and colorectal cancer risk. Near-term physical activity was associated with a small reduction in the risk of colorectal cancer (HR >= 35 vs. <3.5 MET-hr/week, 0.71; 95% CI, 0.53-0.96). The strength and direction of associations were similar for long-term physical activity, although the associations were not nominally significant. Our results suggest that physical activity is inversely associated with the risk of colorectal cancer for people with Lynch syndrome; however, further confirmation is warranted. The potential modifying effect of physical activity on colorectal cancer risk in people with Lynch syndrome could be useful for risk prediction and support counseling advice for lifestyle modification to reduce cancer risk.
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