期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 14, 期 9, 页码 1133-1141出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.26215
关键词
Noncoding RNAs; Epigenetics; Cardiac hypertrophy; miRNAs; LncRNAs
资金
- Natural Science Foundation of China [31701733, 81470522, 31430041]
- Applied Basic Research Programs of Qingdao, China [17-1-1-46-jch]
- Shandong Provincial Natural Science Foundation, China [ZR2016CQ31]
Cardiac hypertrophy is an adaptive enlargement of myocardium in response to pressure overload caused various pathological insults, which is accompanied by alteration of a complex cascade of signaling pathways. During the hypertrophy process, many changes occur at cellular level including gene reprogramming by turning off chromatin regulators. Studies from the past decade have demonstrated that the abnormal epigenetic modifications, such as DNA methylation, histone modification, and oxidative modification of nucleic acid, could lead to changes in chromosome structure and cardiac dysfunction. Increasing evidence indicates that non-coding RNAs (ncRNAs) have functional significance in modulating the gene expression during those pathological events in the heart. Emerging evidences have highlighted that ncRNAs might serve as a signal for changing the state of chromatin, however, the knowledge about the ncRNA-linked epigenetic regulatory mechanisms in cardiac pathologies is still largely unexplored. In this review, we summarize the current information on association between ncRNAs and epigenetic modifications in cardiac hypertrophy, and we have discussed their crosstalk. In addition, this review provides insights into their therapeutic and diagnostic potential for treating hypertrophic heart disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据