期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 14, 期 9, 页码 1090-1098出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.25996
关键词
retinal ganglion cells; neurodegenerative diseases; oxidative stress; Nrf2; Keap1
资金
- Development and Reform Commission of Jilin province [2015Y031-1]
Retinal ganglion cells (RGCs) are one of the important cell types affected in many ocular neurodegenerative diseases. Oxidative stress is considered to be involved in retinal RGCs death in ocular neurodegenerative diseases. More and more attention has been focused on studying the agents that may have neuroprotective effects. Nuclear factor (erythroid-derived2)-like 2 (Nrf2) is a key nuclear transcription factor for the systemic antioxidant defense system. This review elucidates the underlying mechanism of the Nrf2-mediated neuroprotective effects on RGCs in ocular neurodegenerative diseases, such as diabetic retinopathy and retinal ischemia-reperfusion injury. Several Nrf2 inducers that shield RGCs from oxidative stress-induced neurodegeneration via regulating Nrf2 signaling are discussed.
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