期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 109, 期 -, 页码 1006-1011出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.11.085
关键词
Twin-tailed surfactant; Biomacromolecule (HEWL); Modeling; Fluorescence
资金
- UGC [F.7-222/2009(BSR)]
Herein, we have examined the interaction of oxy-diester novel twin tailed (gemini) surfactant, 2,2'-[(oxybis(ethane-1,2-diyl))bis(oxy)bis(N-hexadecyl-N,Ndimethyl-2-oxoethanaminium) dichloride (C-16-E2O-C-16) with hen egg white lysozyme (HEWL), utilizing a spectroscopic and molecular docking spectroscopic results validated the conformational, structural and micro-environmental changes in HEWL upon interaction with C-16-E2O-C-16. Molecular modeling has shown that C-16-E2O-C-16 binds in the proximity of hydrophobic moieties (Trp-62/108). We believe the results of the current study will assist in designing the surfactant-enzyme systems for their end use as ingredients in pharmaceutical, cosmetic, drug delivery and industrial compilations. In terms of scientific literature standpoint, it will also enrich and widen the scope of biomacromolecule-surfactant interactions. (C) 2017 Elsevier B.V. All rights reserved.
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