期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 118, 期 -, 页码 1511-1517出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.06.168
关键词
Solution plasma; Low molecular weight chitosan; Antimicrobial activity; Antioxidant activity; Biomaterials
资金
- Incheon Green Environment Center at Incheon National University in 2017
Low molecular weight (LMW) chitosan has been a great attention in bio-molecular chemistry, medicine, and drug delivery system in particular. Depolymerization of high molecular weight (HMW) chitosan to LMW chitosan was achieved by solution plasma process (SPP) without affecting its chemical structures. Chitosan in solution was depolymerized by discharging plasma at 800 V with 35 kHz for various times (15-120 min). Gel permeation chromatography analysis revealed that molecular weight of chitosan decreased from 3.0 x 10(5) Da to 7.8 x 10(3) Da in 30 mm plasma treatment, and further to 4.6 x 10(3) Da in 90 min. Dynamic light scattering and zeta potential studies confirmed formation of chitosan nano-aggregates. Interestingly, the LMW chitosan samples showed antimicrobial activity against Escherichia coil, Staphylococcus aureus, and Candida albicans with minimal inhibitory concentration of 80-1200 mu g.ml(-1). They also exhibited an excellent antioxidant activity (58-75%) and swelling ratio of 0.2-2.0 mg.mg(-1), LMW chitosan was likely to have potential for sustainable usage as carrier molecules, biomaterials, and biomedical applications. (C) 2018 Elsevier B.V. All rights reserved.
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