期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 113, 期 -, 页码 51-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.02.096
关键词
Green synthesis; Silver nanoparticles; Wound dressing
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [300927/2015-0]
- Secretaria de Desenvolvimento Economico, Ciencia e Tecnologia do RS (SDECT) - Programa de Apoio aos Polos Tecnologicos do RS
This manuscript was focused on introducing a facile, green and scalable method to produce kappa-carrageenan (KC) hydrogel membranes containing in situ synthesized silver nanoparticles (AgNPs). In a typical protocol, KC hydrogels were obtained by heating (sol phase), followed by cooling (gel phase) the polysaccharide solution, which enabled the simultaneous synthesis of AgNPs during the heating time. The as synthesized AgNPs were characterized spectrophotometrically, and by dynamic light scattering and transmission electron microscopy. The swelling properties at different pH and the antimicrobial activity of KC-AgNP hydrogel were investigated. AgNPs were mostly spherical in shape, crystalline in nature and measuring ca. 27 nm in diameter. The in situ synthesis of AgNPs changed the swelling properties of KC hydrogel and also reduces its viscosity and gelling temperature. The AgNPs were continuously released from KC hydrogel for up to 48 h in a concentration sufficient to prevent the bacterial growth as confirmed by antimicrobial tests. The simplicity involved in the AgNPs synthesis combined to the good spreadability of KC hydrogel makes this method suitable for scale-up to manufacturing quantities of wound dressing. (C) 2018 Published by Elsevier B.V.
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