期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 111, 期 -, 页码 696-705出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.01.061
关键词
Nanocomposite hydrogel; Carboxymethyl cellulose; Montmorillonite; Drug delivery
The main aim of the present study was to design pH-sensitive nanocomposite hydrogel beads, based on carboxymethyl cellulose (CMC) and montmorillonite (Mt)-propranolol (PPN) nanohybrid, and evaluate whether the prepared nanocomposite beads could potentially be used as oral drug delivery systems. PPN as a model drug-was intercalated into the interlayer space of Mt clay mineral via the ion exchange procedure. The resultant nanohybrid (Mt-PPN) was applied to fabricate nanocomposite hydrogel beads by association with carboxymethyl cellulose. The characterization of test samples was performed using different techniques: X-Ray Diffraction (XRD), IR spectroscopy (FT-IR), thermal gravity analysis (TGA), and scanning electron microscopy (SEM). The drug encapsulation efficiency was evaluated by UV-vis spectroscopy, and was found to be high for Mt/CMC beads. In vitro drug release test was performed in the simulated gastrointestinal conditions to evaluate the efficiency of Mt-PPN/CMC nanocomposite beads as a controlled-release drug carrier. The drug release profiles indicated that the Mt-PPN/CMC nanocomposite beads had high stability against stomach acid and a sustained and controlled-release profile for PPN under the simulated intestinal conditions. (C) 2018 Elsevier B.V. All rights reserved.
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