Synthesis of Aloevera/Acrylonitrile based Nanoparticles for targeted drug delivery of 5-Aminosalicylic acid

Aloevera (AV) polysaccharidelacrylonitrile (AN) nanoparticles (AVA(Np4) of similar to 50 nm size) have been crafted via free radical polymerization method using persulfate/ascorbic acid (KPS/AA) and methylenebisacrylamide (MBA) as the redox initiator and crosslinker respectively. AVA(NP4) was extensively characterized using FTIR, SEM, TEM, XRD, and Thermal analysis (TGA & DTG). Inclusion of AN in AV polysaccharide has been evidenced by nitrile stretching peak at 2244 cm(-1) in FTIR spectrum of AVA(Np4). Colon specific targeted in-vitro release of 5-Aminosalicylic acid from AVA(Np4) has been studied in pH 1.2 and pH 7.4 buffer solutions at 37 degrees C. The controlled release was witnessed up to 48 h for AVA(Np4) in contrast to AV for which the release exhausted within 7-8 h in both the buffers. The delayed release of the drug from AVA(Np4) is attractive since it can allow the drug to reach colon rather than being released in the upper part of the gastrointestinal tract. (C) 2017 Elsevier B.V. All rights reserved.