期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 106, 期 -, 页码 39-47出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.07.179
关键词
Silk; Non-woven fabric; Sericin
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF- 2017R1A2B4003655]
Electro-spun regenerated silk webs have been extensively studied for biomedical applications because of the simplicity of their fabrication methods However, the productivity of the electro-spinning process is low for web fabrication and the mechanical properties of the electro-spun silk web are not satisfactory, which restricts its commercialization. In this study, a new silk non-woven fabric was successfully fabricated by wetting and hot press treatments using the excellent binding characteristic of sericin. The effects of the press temperature and residual sericin content on the preparation, structure, and properties of the silk non-woven fabric were examined. A press temperature of 200 degrees C was optimum for obtaining non-woven fabrics with best mechanical properties, without yellowing. The silk non-woven fabric could not be fabricated without sericin, and a minimum of 8% sericin was required to fabricate it. As the sericin content was increased, the strength and Young's modulus of the silk non-woven fabric increased, while the tensile elongation remained constant. Regardless of the press temperature and sericin content, all the silk non-woven fabrics showed good cell viability, comparable to that of the tissue culture plate (TCP) used as a control until 4 days, which however decreased compared to that of TCP after 7 days. (C) 2017 Elsevier B.V. All rights reserved.
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