期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 114, 期 -, 页码 1338-1344出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.03.166
关键词
Alginate aerogel; pH/temperature sensitive; Drug controlled release
资金
- National Natural Science Foundation of China [51361009]
- Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education [AM2017-23]
- Key Research and Development Program of Hainan Province [ZDYF2018016]
Alginate was grafted with NIPAM and NHMAM successfully, and a new responsive copolymer, alginate-g-P(NIPAM-co-NHMAM), was obtained. A novel dual responsive polysaccharide-based aerogel with thermo/pH sensitive properties was designed from the copolymer as drug controlled release system. The chemical structure of the copolymer was characterized by FT-IR and H-1 NMR. Lower critical solution temperature (LCST) of the copolymer covered a wide temperature range from 27.6 degrees C to 42.2 degrees C, which could be adjusted with changing the ratio between NIPAM and NHMAM. The dual responsive aerogel had a three-dimensional network structure. As a drug controlled release system, the aerogel was high responsive to both temperature and pH with drug loading efficiency up to 13.24%. Above LCST, the aerogel had a faster drug release, and drug was completely released in neutral environment, while the drug release was obstructed in acid environment. Furthermore, the drug release mechanism of the aerogel was illuminated. These results indicated that the dual responsive aerogel was a promising candidate for drug carriers. (C) 2018 Elsevier B.V. All rights reserved.
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