期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 114, 期 -, 页码 584-591出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.02.033
关键词
Armillaria mellea; Polysaccharides; Galactofucan; Anti-inflammation
资金
- [MOST 105-2320-B-077-002-MY3]
- [MOHW106-NRICM-B-315-000202]
- [MOST 1032320-B-002-006-MY3]
A xylosyl 1,3-galactofucan (AMPS-III) was isolated and identified as a novel anti-inflammatory agent from an edible fungus, Armillaria mellea. The characteristics chemical structure of AMPS-HI including the linkages of compositional monosaccharides and structure of the repeat unit were depicted and elucidated by proton, carbon and two-dimensional nuclear magnetic resonance techniques. AMPS-III was chemically proposed to have a partial 4-O-xylosylated 1,3-linked alpha-D-galactosyl-interlaced alpha-L-fucan composed of a pentadecasaccharide repeat unit with a molecular mass approximately 13 kDa. AMPS-HI significantly suppressed the release of tumor necrosis factor-a (TNF-alpha) and cytokine monocyte chemotactic protein-1 (MCP-1) in RAW264.7 macrophages and EAhy926 following LPS and TNF-alpha induction. The results provide helpful evidences for application of AMPS-Ill as anti-inflammatory food supplements. (C) 2018 Published by Elsevier B.V.
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