期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 113, 期 -, 页码 285-293出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.02.083
关键词
Konjac glucomannan; Microcrystalline cellulose; Poly(dopamine); Intelligent hydrogels; pH-responsive sustained release behavior
资金
- National Natural Science Foundation of China [31471704, 31772045]
- Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University [324-1122yb034]
Intelligent hydrogels are attractive biomaterials for various applications, however, fabricating a hydrogel with both adequate self-healing ability and mechanical properties remains a challenge. Herein, a series of novel intelligent konjac glucomannan (KGM)/microcrystalline cellulose (MCC) hydrogels were prepared vis the mussel-inspired chemistry. MCC was firstly functionalized by the oxidative polymerization of dopamine, and the intelligent hydrogels were obtained by mixing aqueous solutions of KGM and functionalized MCC (PDMCC). By introducing PDMCC, a more compact interconnected porous structure formed for the resulting hydrogels. The self-healing ability and mechanical properties of intelligent hydrogels were dependence on the PDMCC content. Compared with KGM hydrogels, KGM/PDMCC hydrogels exhibited a more distinct pH sensitivity and a lower initial burst release, which was attributed to the compact structure and strong intermolecular hydrogen bond interaction between PDMCC and KGM. These results suggest that the KGM/PDMCC intelligent hydrogels may be promising carriers for controlled drug delivery. (C) 2018 Elsevier B.V. All rights reserved.
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