期刊
GENE
卷 568, 期 2, 页码 203-210出版社
ELSEVIER
DOI: 10.1016/j.gene.2015.05.058
关键词
Drosophila; Erk; Glutathione transferase omega; Hydrogen peroxide; MAPK pathway; Neuronal cell
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) [2014R1A1A2058027, 2014R1A1A2005183]
- Soonchunhyang University Research Fund
- National Research Foundation of Korea [2014R1A1A2005183, 2014R1A1A2058027] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Glutathione transferase omega (GSTO) belongs to a recently identified family of glutathione transferase (GST) and presents several known functions. In Drosophila, despite the high sequence identity among the four GstO isoforms, they present different physiological functions. Herein, we showed that GstO1, which is one of the Drosophila GstOs, is highly expressed in adult heads. We determined the three-dimensional structure of GstO1, by homology modeling. Furthermore, we show that GstO1 loss-of-function mutant flies display reduced survival than the control flies when subjected to H2O2 treatment. Interestingly, the neuronal-specific expression of GstO1 in a GstO1 loss-of-function mutant background rescued H2O2-induced toxicity. We further showed that GstO1 inhibits H2O2-mediated activation of the mitogen-activated protein kinase (MAPK) pathway. Collectively, our findings provide valuable new insights into the tissue-specific protective mechanisms of Drosophila GstOs during oxidative stress. (C) 2015 Elsevier B.V. All rights reserved.
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