期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 114, 期 -, 页码 363-372出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.03.147
关键词
Ampholytic cellulose; Tosyl cellulose; In vitro cytotoxicity
资金
- Academy of Scientific Research and Technology, Egypt through Egypt-France Scientific and Technological Cooperation Program MHOTEP
The development of new biocompatible, biodegradable functionalized biopolymers that can serve as scaffold for tissue regeneration or work as carriers for different bioactive molecules such as drugs, proteins, and enzymes remains a continuous challenge that need to be extensively explored. For this purpose, three water-soluble cellulose derivatives; namely 4(celluloseamino) butyric acid (CABA) 2 (celluloseamino) succinic add (CASA), and 3 (celluloseamino) propane sulfonic adds (CAPSA) were synthesized from microcrystalline cellulose (MCC) via esterification with tosyl chloride that was followed by nucleophilic substitution by the proper aminoalkyl acid derivative. The products were characterized by elemental analyses, FTIR, C-13 NMR spectroscopy. The thermal stability, surface morphology, and the elemental composition of the new ampholytic biopolymers were also studied by TGA, EDX-SEM. The new ampholytic cellulose derivatives were evaluated for their in vitro cytotoxicity on normal human retina cell line (RPE1) by MTT assay. (C) 2018 Published by Elsevier B.V.
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