期刊
GENE
卷 565, 期 2, 页码 155-165出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.04.066
关键词
Testis development; Wnt signaling; Testis determination; Sertoli cell; Spermatogenesis
资金
- National Natural Science Foundation of China [41276151]
- Zhejiang Provincial Natural Science Foundation of China [Y15H040004]
Testis development is a fundamental process in sexual development and reproduction. It is under the regulation of multiple factors. Wnt signaling pathway is a classical pathway, which plays an essential role during early development. From a traditional view, Wnt signaling serves as a key regulator of female reproductive system. However, its role in testis development is relatively controversial. This paper reviews Wnt signaling's part in the major events during testis development, including primordial germ cell specification, proliferation and migration, testis determination, spermatogenesis and somatic cell regulation, and summarizes Wnt signaling's impact on testis-related disorders. We evaluate the outcomes of current studies in the field and suggest future research directions. (C) 2015 Elsevier B.V. All rights reserved.
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