期刊
ACTA VIROLOGICA
卷 58, 期 4, 页码 368-373出版社
AEPRESS SRO
DOI: 10.4149/av_2014_04_368
关键词
herpes simplex virus 1; flavonoid; Polygonum perfoliatum L.; antiviral; Hep-2 cell; mouse
类别
Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.
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