期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 57, 期 -, 页码 62-71出版社
ELSEVIER
DOI: 10.1016/j.intimp.2018.01.041
关键词
Proinflammatory; Anti-inflammatory; Histopathology; Pathway elucidation
资金
- CSIR [BSC 0110]
- DST [GAP 2107]
- Department of Science and Technology, New Delhi
Kaempferol-3-O-beta-D-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1 beta, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo. Further molecular insights into the study reveal that K3G blocks the phosphorylation of NF-kappa B which is key regulator of inflammation, thereby exhibiting anti-inflammatory potential. Hence, this study permits further investigation to develop K3G as anti-inflammatory drug.
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