期刊
INTERNATIONAL IMMUNOLOGY
卷 30, 期 9, 页码 419-428出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxy015
关键词
animal models; Asian and European AD; extrinsic and intrinsic AD; pediatric AD; psoriasis
类别
资金
- Japan Society for the Promotion of Science [15H05790, 24591649, 15K09765, 15H1155, 15K15417]
- Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO) [16021031300]
- Japan Agency for Medical Research and Development (AMED) [16ek0410011h0003, 16he0902003h0002]
- Grants-in-Aid for Scientific Research [15K15417, 15H05906, 24591649, 15K09765] Funding Source: KAKEN
Atopic dermatitis (AD) is a common T-cell-mediated inflammatory disease of the skin. Signatures of AD are characterized by an impaired skin barrier, aberrant T(h)2-type cytokine production and intensive pruritus. Transcriptomic analysis, however, has revealed a heterogeneous pathogenesis and the co-existence of multiple cytokine axes of T(h)17, T(h)22 and T(h)1 types, especially in intrinsic (a subtype of AD without skin barrier impairment), pediatric and Asian types of AD. Furthermore, the therapeutic effect of anti-IL-4 receptor a against AD was not as high as that of IL-17 blockage against psoriasis, which implies a modification of the disease spectrum by non-T(h)2-type cytokine axes in AD. These lines of evidence indicate a need for personalized or precision medicine appropriate for each subtype of AD.
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