Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris

Objective: To investigate whether sodium tanshinone IIA silate (STS) as an add-on therapy to conventional treatment may provide additional benefits for patients with unstable angina pectoris (UAP) and is associated with changes in profiles of serum inflammatory factors. Methods: Eighty patients diagnosed with UAP were randomly divided into two groups for the 2-week treatment. The control group received conventional therapy, while the treatment group was given intravenous STS (0.06 mg in 250 mL, once daily) as an add-on therapy to the conventional medications. The therapeutic efficacy and changes in serum levels of several inflammatory cytokines, including monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), peroxisome proliferator-activated receptor (PPAR-gamma), and high-sensitivity C-reactive protein (hs-CRP) from baseline were determined and compared between the two group. Results: The clinical symptoms of all patients in both groups were improved after treatment. The overall rate of effectiveness was 97.5% in the treatment group vs. 80.0% in the control group. Serum levels of MCP-1, TNF-alpha, and hs-CRP levels were significantly reduced in both groups (P<0.01), whereas the reduction was greater in patients receiving additional STS (P<0.05). PPAR-gamma was significantly elevated in both groups (P<0.01). Conclusions: STS in combination with conventional treatment may be associated with better outcomes in patients with UAP.