期刊
INORGANIC CHEMISTRY
卷 57, 期 9, 页码 5420-5428出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.8b00384
关键词
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资金
- NSFC [21671122, 21475078, 21501111, 21401118]
- Natural Science Foundation of Shandong Province [ZR2014BP011, ZR2016BQ25]
Nanocrystallization of organic molecular photosensitizers (PSs) by means of NMOF platforms has been demonstrated to be a promising approach to build up highly efficient PDT therapeutics. We report herein a new UiO-66 type of NMOF-based PS (UiO-66-TPP-SH), which is generated from UiO-66 NMOF and S-ethylthiol ester monosubstituted metal free porphyrin (TPP-SH) via a facile postsynthetic approach under mild conditions. The obtained NMOF (size less than 150 nm) with surface-decorated porphyrinic PS can not only retain MOF crystallinity, structural feature, and size, but also exhibit highly efficient singlet oxygen generation. Compared to the interior-located porphyrinic NMOF, UiO-66TPP-SH shows significantly higher photodynamic activity and more efficient PDT tumor treatment.
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