期刊
INFECTION GENETICS AND EVOLUTION
卷 62, 期 -, 页码 279-295出版社
ELSEVIER
DOI: 10.1016/j.meegid.2018.04.032
关键词
Dengue virus; Evolution; Phylogenetics; Molecular epidemiology
资金
- NIH [R01AI114703]
- McKenzie fellowship from the University of Melbourne
- NRC fellowship from the National Academies
- US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Branch [P0082_18_WR]
Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae. aegypti and Ae. albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applied as a public health tool against this arboviral pathogen.
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