期刊
INFECTION GENETICS AND EVOLUTION
卷 57, 期 -, 页码 46-50出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2017.11.007
关键词
Rotavirus; Molecular epidemiology; Diarrhea; G3; Full-genome
The genetic heterogeneity of rotaviruses constitutes a substantial burden to human and animal health. Occasional interspecies transmissions can generate novel virus strains in the human population. We detected equine-like G3P[8] strains in feces sampled from three children in Germany in 2015 and 2016, respectively. Thereof two showed a DS-1-like backbone. In one strain the NSP2 gene segment was of distinct genotype ( G3-P [8]-I2-R2-C2-M2-A2-N1-T2-E2-H2). Phylogenetic analyses of the German strains showed a relation to other equine-like G3 rotaviruses circulating in different countries. The reconstruction of reassortment events in the evolution of novel equine-like G3 rotaviruses suggests an independent introduction of the three strains into the local human rotavirus population.
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