期刊
INFECTION AND IMMUNITY
卷 86, 期 4, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00934-17
关键词
inferior turbinate; nasal mucosa; commensal microbiota; immunoglobulin E; multiple-allergen simultaneous test; skin prick test; allergic rhinitis; Staphylococcus aureus; Propionibacterium acnes
资金
- Collaborative Genome Program for Fostering New Post-Genome industry [2015M3C9A2054299]
- Global Research Lab program [2016K1A1A2910779]
- Mid-career Researcher Program through the National Research Foundation of Korea (NRF) - Ministry of Science ICT & Future Planning [2016R1E1A1A02921587]
- National Research Foundation of Korea [2016R1E1A1A02921587] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Abnormalities in the human microbiota are associated with the etiology of allergic diseases. Although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. We sought to characterize the microbiota of the site of allergic rhinitis, the inferior turbinate, in subjects with allergic rhinitis (n = 20) and healthy controls (n = 12) and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, and allergen-specific and total IgE levels. Microbial dysbiosis correlated significantly with total IgE levels representing combined allergic responses but not with disease occurrence, the number of sensitized allergens, or house dust mite allergen-specific IgE levels. Compared to the populations in individuals with low total IgE levels (group IgE(low)), low microbial biodiversity with a high relative abundance of Firmicutes phylum (Staphylococcus aureus) and a low relative abundance of Actinobacteria phylum (Propionibacterium acnes) was observed in individuals with high total serum IgE levels (group IgE(high)). Phylogeny-based microbial functional potential predicted by the 16S rRNA gene indicated an increase in signal transduction-related genes and a decrease in energy metabolism-related genes in group IgE(high) as shown in the microbial features with atopic and/or inflammatory diseases. Thus, dysbiosis of the inferior turbinate mucosa microbiota, particularly an increase in S. aureus and a decrease in P. acnes, is linked to high total IgE levels in allergic rhinitis, suggesting that inferior turbinate microbiota may be affected by accumulated allergic responses against sensitized allergens and that site-specific microbial alterations play a potential role in disease pathophysiology.
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