期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 2, 页码 1327-1333出版社
AMER CHEMICAL SOC
DOI: 10.1021/am507689a
关键词
CoFe2O4; bioinspired; micros; controlled release
资金
- National Natural Science Foundation of China [91333203]
- Natural Science Foundation of Zhejiang province [LY14E020006]
- Doctorate Fund of the Ministry of Education [2011010110013]
Bioinspired by the morphology of dandelion pollen grains, we successfully prepared a template-free solution-based method for the large-scale preparation of three-dimensional (3D) hierarchical CoFe2O4 porous microspheres. Besides, on the basis of the effect of the reaction time on the morphology evolution of the precursor, we proposed an in situ dissolution-recrystallization growth mechanism with morphology and phase change to understand the formation of dandelion pollenlike microspheres. Doxorubicin hydrochloride, an anticancer drug, is efficiently loaded into the CoFe2O4 microspheres. The magnetic nanoparticles as field-controlled drug carriers offer a unique power of magnetic guidance and field-triggered drug-release behavior. Therefore, 3D hierarchical CoFe2O4 porous microspheres demonstrate the great potential for drug encapsulation and controlled drug-release applications.
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