Preparation and Evaluation of Mucoadhesive Nanoparticles of Rosuvastatin

Mucoadhesive nanoparticles constitute one of the important novel drug delivery systems, which cause localization of the drug at the site of absorption. The aim of this study was to prepare mucoadhesive nanoparticles of rosuvastatin calcium, an antilipidemic agent. Rosuvastatin calcium nanoparticles were prepared by employing the precipitation technique and were characterized using Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy and by estimating their zeta potential and in vitro drug release. Results indicated that gastroretentive nanoparticle formulation could be developed to release rosuvastatin for up to 8 hours in the stomach.