期刊
INDIAN JOURNAL OF MEDICAL RESEARCH
卷 147, 期 -, 页码 341-351出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/ijmr.IJMR_524_18
关键词
Menopause; oestrogens; oxidative stress; post-menopausal osteoporosis; reactive oxygen species; redox homeostasis
资金
- 'Local Research Project' grant from University of Ferrara, Italy
Post-menopausal osteoporosis (PO) is one of the major health issues associated with menopause-related oestrogen withdrawal. Despite the intense research and the relevant progress achieved in the last two decades, the pathogenic mechanism underlying PO is still poorly understood. As a consequence of this gap in the knowledge, such disorder and the related complications are still difficult to be effectively prevented. A wealth of experimental and epidemiological/clinical evidence suggests that the endocrine change associated to menopausal transition might lead to a derangement of redox homeostasis, that is, the prelude to the health-threaten condition of oxidative stress (OxS). In turn, this (bio) chemical stress has been widely hypothesized to contribute, most likely in synergy with inflammation, to the development of menopause-related diseases, including PO. The main aim of this review is to discuss the current literature evidence on the association between post-menopausal oestrogen withdrawal, OxS and PO. It is also aimed to provide a critical overview of the most significant epidemiological studies on the effects of dietary antioxidants on bone health and to devise a strategy to overcome the limitations emerged and controversial results.
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