期刊
IMMUNOTHERAPY
卷 10, 期 2, 页码 93-105出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2017-0121
关键词
checkpoint inhibitor; immunotherapy; non-small-cell lung cancer; pembrolizumab
类别
资金
- Merck & Co., Inc., Kenilworth, NJ, USA
This review describes trials evaluating the monoclonal antibody pembrolizumab (an immunotherapy that blocks the interaction between programmed death-1 and programmed death-ligand 1 and 2 [PD-L1/PD-L2]) as first-line therapy for advanced non-small-cell lung cancer (NSCLC). In the Phase III KEYNOTE-024 study, pembrolizumab monotherapy significantly improved progression-free survival (primary end point) and overall survival, and was associated with fewer adverse events compared with platinum-based chemotherapy in patients with NSCLC with PD-L1 expression on >= 50% of tumor cells. In cohort G of the Phase I/II KEYNOTE-021 study, pembrolizumab plus pemetrexed and carboplatin significantly improved objective response rate (primary end point) and progression-free survival versus pemetrexed and carboplatin alone, and had manageable toxicity in patients with nonsquamous NSCLC. These results have changed first-line management of advanced NSCLC.
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