期刊
IMMUNOLOGY LETTERS
卷 193, 期 -, 页码 51-57出版社
ELSEVIER
DOI: 10.1016/j.imlet.2017.11.011
关键词
Cord blood; CD4; T cell; Th1; Th2; CD26; IL-13
类别
资金
- Van Kampen Cardiopulmonary Research Fund
- [NIHRO1AI 100129]
- [PO1 CA154778]
It has been generally considered that the perinatal immune system is less inflammatory compared to the adult system and type 2 responses predominate perinatal immune responses against antigens. Indeed, previous studies in mice showed that there are cell-intrinsic differences between neonatal and adult CD4 T cells. However, studies on human cord blood and infant blood demonstrated that human perinatal T cells do not produce elevated levels of Th2 cytokines with the exception of IL-13. These data raise the question if human T cells in the perinatal blood fundamentally differ from adult T cells. To decipher differences between human perinatal and adult T cells, we performed a focused comparative analysis on purified naive CD4 T cells from umbilical cord blood (UCB) and adult peripheral blood. Our data demonstrate nave CD4 T cells from UCB differ from adult nave CD4 T cells in surface expression of CD26, dipeptidyl peptidase-4. While only a fraction of effector/memory T cells from adult blood express CD26, practically all T cells from UCB express high levels of CD26. We also determined that Thl/Th2 polarizing conditions induce UCB CD4 T cells to produce higher levels of IFN-gamma and IL-5 compared to adult CD4 T cells, respectively. These data demonstrate intrinsic differences between UCB and adult naive CD4 T cells and suggest that human perinatal immune responses involve more complex mechanisms than the previously thought Th2-dominant responses.
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