期刊
IMMUNOLOGY LETTERS
卷 195, 期 -, 页码 45-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2017.10.011
关键词
Interferon; Systemic sclerosis; Cytokines; Fibrosis; Vasculopathy; Autoimmunity; IFN signaling; Anifrolumab
类别
资金
- National Science Centre (Poland) [2015/16/S/NZ6/00041]
Systemic Sclerosis (SSc) is an autoimmune disease characterised by vasculopathy, uncontrolled inflammation and enhanced fibrosis which can subsequently lead to the loss of organ function or even premature death. Interferons (IFNs) are pleiotropic cytokines that are critical not only in mounting an effective immune response against viral and bacterial infections but also strongly contribute to the pathogenesis of SSc. Furthermore, elevated levels of IFNs are found in SSc patients and correlate with skin thickness and disease activity suggesting potential role of IFNs as biomarkers. In this review, we summarise existing knowledge regarding all types of IFNs and IFN-inducible genes in the pathogenesis of SSc. We then argue why IFN-blocking strategies are promising therapeutic targets in SSc and other autoimmune diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据