期刊
IMMUNOLOGY
卷 154, 期 4, 页码 537-546出版社
WILEY
DOI: 10.1111/imm.12950
关键词
autoimmunity; immune homeostasis; microbiota; mucosal immunology; segmented filamentous bacteria; Th17 cells
类别
资金
- Alberta Innovates and AbbVie/Canadian Association of Gastroenterology/Canadian Institutes for Health Research
- National Institutes of Health [1R01DK097256]
Segmented filamentous bacteria (SFB) are Gram-positive, spore-forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and adaptive immune cell activation. The cardinal features of SFB-induced gut immunity - T helper type 17 (Th17) cell differentiation, IgA production and barrier protection - lead to the containment of SFB and further afford protection against invading pathogens. Th17 cells and interleukin-17A, however, can also reach peripheral sites and exacerbate autoimmunity. In this review, we highlight salient characteristics of SFB-host interactions and detail the cellular and molecular immune mechanisms involved in coordinating these responses.
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