期刊
IMMUNOLOGY
卷 154, 期 3, 页码 354-362出版社
WILEY
DOI: 10.1111/imm.12917
关键词
acidity; cancer; hypoxia; immunotherapy; microenvironment
类别
资金
- NCI NIH HHS [R01 CA187532, U54 CA193489] Funding Source: Medline
Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia and acidosis, which have significant influences on remodelling both tumour and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance. Understanding these effects and characterizing the pathways involved can identify new targets for therapy and may redefine our understanding of traditional anti-tumour therapies. In this review, the effects of hypoxia and acidosis on tumour immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions is discussed.
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