期刊
IMMUNOLOGY
卷 154, 期 1, 页码 50-61出版社
WILEY
DOI: 10.1111/imm.12906
关键词
Haematopoiesis; humanized mice; immune system; stem cell; viral
类别
资金
- Wellcome Trust [104771/Z/14/Z] Funding Source: Medline
- Wellcome Trust [104771/Z/14/Z] Funding Source: Wellcome Trust
- Wellcome Trust [104771/Z/14/Z] Funding Source: researchfish
Humanized mice are increasingly appreciated as an incredibly powerful platform for infectious disease research. The often very narrow species tropism of many viral infections, coupled with the sometimes misleading results from preclinical studies in animal models further emphasize the need for more predictive model systems based on human cells rather than surrogates. Humanized mice represent such a model and have been greatly enhanced with regards to their immune system reconstitution as well as immune functionality in the past years, resulting in their recommendation as a preclinical model by the US Food and Drug Administration. This review aims to give a detailed summary of the generation of human peripheral blood lymphocyte, CD34(+) haematopoietic stem cell- and bone marrow/liver/thymus-reconstituted mice and available improved models (e.g. myeloid- or T-cell-only mice, MISTRG, NSG-SGM3). Additionally, we summarize human-tropic viral infections, for which humanized mice offer a novel approach for the study of disease pathogenesis as well as future perspectives for their use in biomedical, drug and vaccine research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据