期刊
IMMUNOLOGICAL REVIEWS
卷 282, 期 1, 页码 168-187出版社
WILEY
DOI: 10.1111/imr.12622
关键词
atopic dermatitis; cancer; itch; mast cell; mastocytosis; neurogenic inflammation; pain; pruritus; psoriasis; sickle cell disease
类别
资金
- Kuopio University Hospital
- Cancer Center of Eastern Finland
- National Heart, Lung, and Blood Institute [R01 HL103773, UO1 HL117664]
- NIH [UO1 HL117664, R01HL103773]
- VTR-funding of Kuopio University Hospital
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL103733, U01HL117664] Funding Source: NIH RePORTER
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a power house by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus. Mechanisms underlying mast cell differentiation, activation, and intercellular interactions with inflammatory, vascular, and neural systems are deeply influenced by their microenvironment, imparting enormous heterogeneity and complexity in understanding their contribution to pain and pruritus. Neurogenic inflammation is central to both pain and pruritus, but specific mediators released by mast cells to promote this process may vary depending upon their location, stimuli, underlying pathology, gender, and species. Therefore, in this review, we present the contribution of mast cells in pathological conditions, including distressing pruritus exacerbated by psychologic stress and experienced by the majority of patients with psoriasis and atopic dermatitis and in different pain syndromes due to mastocytosis, sickle cell disease, and cancer.
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