HSA loaded with CoFe2O4/MNPs as a high-efficiency carrier for epirubicin anticancer drug delivery

Drug delivery is one of the most important challenges in the domain of health. Non-toxic and biocompatible carriers are provided by human serum albumin nano-capsule (HSA/NC) for drug delivery applications. In this study, HSA, with high loadings of drug-modified cobalt ferrite (CoFe2O4) magnetic nanoparticle (CoFe2O4/MNPs) was fabricated for epirubicin anticancer drug delivery. In the initial step, CoFe2O4/MNPs was synthesised via co-precipitation technique and characterised by X-ray powder diffraction, vibrating sample magnetometry, energy dispersive X-ray analysis, scanning electron microscopy and map analysis. Furthermore, CoFe2O4/MNPs and epirubicin were loaded into HSA/NC and utilised as a novel system against breast cancer cell line (MCF-7). IC50 for free epirubicin, unloaded CoFe2O4/MNPs/HSA/NC, CoFe2O4/MNPs and epirubicin-loaded CoFe2O4/MNPs/HSA/NC were 7.7, 2400, 840 and 430g/ml, respectively. The results obtained revealed high cytotoxicity effect of epirubicin-loaded CoFe2O4/MNPs on breast cancer cell line.