期刊
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
卷 15, 期 1, 页码 109-116出版社
IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2016.2615931
关键词
Protein-protein interaction network; essential proteins; gene ontology; gene expression profile
类别
资金
- Natural Science Foundation of Jiangxi Province [20161BAB211022]
- Major Research Plan of the National Natural Science Foundation of China [91530320]
- Chinese National Natural Science Foundation [61672388]
- Research Foundation of Hubei Province Department of Education [Q20151505]
The identification of essential proteins in protein-protein interaction (PPI) networks is of great significance for understanding cellular processes. With the increasing availability of large-scale PPI data, numerous centrality measures based on network topology have been proposed to detect essential proteins from PPI networks. However, most of the current approaches focus mainly on the topological structure of PPI networks, and largely ignore the gene ontology annotation information. In this paper, we propose a novel centrality measure, called TEO, for identifying essential proteins by combining network topology, gene expression profiles, and GO information. To evaluate the performance of the TEO method, we compare it with five other methods (degree, betweenness, NC, Pec, and CowEWC) in detecting essential proteins from two different yeast PPI datasets. The simulation results show that adding GO information can effectively improve the predicted precision and that our method outperforms the others in predicting essential proteins.
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