Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward b-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.