期刊
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
卷 26, 期 6, 页码 1111-1120出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNSRE.2018.2832055
关键词
Retinal prosthesis; admittance method; multi-scale modeling; connectome; electrical stimulation
资金
- National Institute of the General Medical Sciences, National Institutes of Health [1U01GM104604-01]
- National Institutes of Health [EY02576, EY015128, EY014800]
- National Science Foundation [0941717]
- Edward N. and Della L. Thome Memorial Foundation
- Research to Prevent Blindness
- NATIONAL EYE INSTITUTE [R01EY002576, R01EY028927, P30EY014800, R01EY015128] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U01GM104604] Funding Source: NIH RePORTER
A computational model of electrical stimulation of the retina is proposed for investigating current waveforms used in prosthetic devices for restoring partial vision lost to retinal degenerative diseases. The model framework combines a connectome-based neural network model characterized by accurate morphological and synaptic properties with an admittance method model of bulk tissue and prosthetic electronics. In this model, the retina was computationally degenerated, considering cellular death and anatomical changes that occur early in disease, as well as altered neural behavior that develops throughout the neurodegeneration and is likely interfering with current attempts at restoring vision. A resulting analysis of stimulation range and threshold of ON ganglion cells within the retina that are either healthy or in beginning stages of degeneration is presented for currently used stimulation waveforms, and an asymmetric biphasic current stimulation for subduing spontaneous firing to allow increased control over ganglion cell firing patterns in degenerated retina is proposed. Results show that stimulation thresholds of retinal ganglion cells do not notably vary after beginning stages of retina degeneration. In addition, simulation of proposed asymmetric waveforms showed the ability to enhance the control of ganglion cell firing via electrical stimulation.
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