期刊
OCULAR ONCOLOGY AND PATHOLOGY
卷 1, 期 3, 页码 190-199出版社
KARGER
DOI: 10.1159/000370155
关键词
Ocular oncology; Retinoblastoma; Uveal melanoma; Drosophila; Cancer model; Ocular cancer
资金
- CRUK
- NWCR
- National Institute for Health Research [ACF-2014-06-002] Funding Source: researchfish
Drosophila has made many contributions to our understanding of cancer genes and mechanisms that have subsequently been validated in mammals. Despite anatomical differences between fly and human eyes, flies offer a tractable genetic model in which to dissect the functional importance of genetic lesions found to be affected in human ocular tumors. Here, we discuss different approaches for using Drosophila as a model for ocular cancer and how studies on ocular cancer genes in flies have begun to reveal potential strategies for therapeutic intervention. We also discuss recent developments in the use of Drosophila for drug discovery, which is coming to the fore as Drosophila models are becoming tailored to study tumor types found in the clinic. (C) 2015 S. Karger AG, Basel
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