期刊
FRONTIERS IN ECOLOGY AND EVOLUTION
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fevo.2015.00039
关键词
odorant receptor; ligand-gated ion channel; synaptic communication; olfactory communication; neurotransmitter receptors
类别
The molecular basis of odorant detection and its corollary, the task of the odorant receptor, are fundamental to understanding olfactory coding and sensory ecology. Based on their molecular receptive range, olfactory receptors have been classified as pheromone and non-pheromone receptors, which are respectively activated by a single pheromone component (specialist) or by multiple odorant ligands (generalist). This functional distinction is unique among ligand-gated ion channels and has shaped how we model olfactory coding both at the peripheral and central levels. Here, we revisit the long-standing combinatorial theory of olfaction and argue, based on physiological, pharmacological, evolutionary, and experimental grounds that the task of the odorant receptor is not different from that of neurotransmitter receptors localized in neuronal synapses.
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