期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2015.00184
关键词
yeast; stress tolerance; cellular stress response; inhibitory environment; ethanol production process; design-based engineering; integrated -omics analysis
资金
- Secretaria de Educacion Publica (SEP) [DSA/103.5/14/10703]
- National Council of Science (CONACyT)
- Novo Nordisk Foundation
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsradet
Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory conditions are ideal for cost-competitive ethanol production from lignocellulose. A major drawback to directly design S. cerevisiae tolerance to inhibitory conditions of lignocellulosic ethanol production processes is the lack of knowledge about basic aspects of its cellular signaling network in response to stress. Here, we highlight the inhibitory conditions found in ethanol production processes, the targeted cellular functions, the key contributions of integrated -omics analysis to reveal cellular stress responses according to these inhibitors, and current status on design-based engineering of tolerant and efficient S. cerevisiae strains for ethanol production from lignocellulose.
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