期刊
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
卷 10, 期 1, 页码 37-59出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1745691614556682
关键词
genetics; candidate genes; GxE; gene-environment interaction
资金
- NIAAA NIH HHS [K02AA018755, K05 AA017242, R21AA21235, U10 AA008401, R01AA018333, K05AA017242, K02 AA018755, R01 AA018333-04S1, U10AA008401, R01 AA018333, R21 AA021235] Funding Source: Medline
- NIDA NIH HHS [DA011015, K02 DA032573, R01 DA023668, P60 DA011015, R01DA23668, K02DA32573, R01DA070312] Funding Source: Medline
- NIMH NIH HHS [K01 MH085812, R01MH100141, K01MH085812, R01 MH100141] Funding Source: Medline
Studying how genetic predispositions come together with environmental factors to contribute to complex behavioral outcomes has great potential for advancing the understanding of the development of psychopathology. It represents a clear theoretical advance over studying these factors in isolation. However, research at the intersection of multiple fields creates many challenges. We review several reasons why the rapidly expanding candidate gene-environment interaction (cGxE) literature should be considered with a degree of caution. We discuss lessons learned about candidate gene main effects from the evolving genetics literature and how these inform the study of cGxE. We review the importance of the measurement of the gene and environment of interest in cGxE studies. We discuss statistical concerns with modeling cGxE that are frequently overlooked. Furthermore, we review other challenges that have likely contributed to the cGxE literature being difficult to interpret, including low power and publication bias. Many of these issues are similar to other concerns about research integrity (e.g., high false-positive rates) that have received increasing attention in the social sciences. We provide recommendations for rigorous research practices for cGxE studies that we believe will advance its potential to contribute more robustly to the understanding of complex behavioral phenotypes.
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