期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 44, 期 1, 页码 205-214出版社
IOS PRESS
DOI: 10.3233/JAD-141053
关键词
Cerebrospinal fluid; dementia; magnetic resonance imaging; mild cognitive impairment; neuropsychological test
资金
- Swedish Research Council [2002-5462, K2002-21P-14359-01A, 09946]
- Swedish Brain Power
- Handlanden Hjalmar Svenssons Forsknings-fond
- Pfannenstills Forskningsstiftelse
- Alzheimer-fonden
- Axel Linders Stiftelse
- Stiftelsen Gamla Tjanarinnor
- Sahlgrenska University Funds
- Royal Swedish Academy of Sciences
- Stiftelsen Psykiatriska Forskningsfonden
Background: Neuropsychological tests, CSF A beta(42,) T-tau, P-tau181, hippocampal volume, and white matter lesions have been shown to predict conversion to dementia in patients with mild cognitive impairment (MCI). Objective: To examine the predictive value of combinations of these markers and to examine if the absence of pathological markers provides a lasting reduction of conversion rates. Methods: The Gothenburg MCI study is a clinically based study. Seventy-three MCI patients were included in the present sub-study and followed for a maximum of ten years. Thirty-four patients converted to dementia (18 to AD) and 39 remained stable. At inclusion, patients were classified into positive or negative risk groups according to results from neuropsychological testing (Rey auditory verbal learning test, Boston naming test, Trail making test B), CSF biomarkers (amyloid beta(42), T-tau, and P-tau181) and MRI scans (hippocampal volume, white matter lesions). Results: Trail making test B (TMT-B) was the best single predictor for the prediction of dementia (AUC 0.89, HR 25), and T-tau was the best predictor ofAD(AUC 0.97, HR 41). The combination of hippocampal volume and TMT-Bwas the best combination for the prediction of dementia (HR 25), and the combination of hippocampal volume and T-tau was the best combination for the prediction of AD (HR 37). Conclusion: Neuropsychological tests, CSF markers, and hippocampal volume predicted conversion from MCI to AD and general dementia. The absence of pathological markers provided a long-time protection from dementia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据