期刊
RSC ADVANCES
卷 5, 期 1, 页码 654-664出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra13427c
关键词
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资金
- National Natural Science Foundation of China [51103031]
- Research Fund for the Doctoral Program of Higher Education of China [20112302120034]
- Special Foundation of China Postdoctoral Science [201003436]
- State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology [QA201415]
- Fundamental Research Funds for the Central Universities [HIT. NSRIF. 2012034]
- China Scholarship Council [201303070100]
The unique structures and properties of nanocarbons will provide fascinating applications in biomedicine. Here we report a new strategy to combine C-60 with graphene for targeting phototherapy. Folic acid (FA) and polyethylene glycol (PEG) were conjugated onto graphene oxide (GO) via an imide linkage. Using nucleophilic addition, the FA-GO-PEG/C-60 nanohybrid was then prepared. The versatile platform of FA-GO-PEG for C-60 dramatically improved tumor targeting, which has been demonstrated by a cellular uptake assay. Owing to the doping effect and the inhibition of aggregation, the hybridization process also significantly enhanced the phototoxicity of FA-GO-PEG/C-60. More importantly, the photothermal therapy (PTT) of FA-GO-PEG/C-60 can cause obvious cell damage, which may further enhance the photodynamic therapy (PDT) efficacy against cancer cells. As expected, the combined PDT and PTT treatment with FA-GO-PEG/C-60 showed remarkably improved and synergistic effects compared to PTT or PDT alone. This study presents the potential of nanocarbons for synergistic phototherapy of cancer.
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