期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 12, 期 3, 页码 510-520出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2018.2821060
关键词
Capacitance measurement; cell culture; CMOS integrated circuits; dielectric measurements; lab on a chip; mixed analog-digital integrated circuits
资金
- UMD-UMB Research and Innovation Seed Grant
- Academy of Finland [268944]
- Academy of Finland (AKA) [268944, 268944] Funding Source: Academy of Finland (AKA)
We describe a capacitance sensor array that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents analyticalmodels, calibration results, and measured experimental results of the biosensor. The sensor has been characterized and exhibits a sensitivity of 590 kHz/fF. We report results from benchtop tests and in vitro experiments demonstrating on-chip tracking of cell adhesion as well as monitoring of cell viability. Human ovarian cancer cells were cultured on chip, and measured capacitance responses were validated by comparison with images from photomicrographs of the chip surface. Analysis was performed to quantify cell proliferation and adhesion, and responses to live cells were estimated to be 100 aF/cell.
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