期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 15, 期 1, 页码 121-126出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-013-0271-4
关键词
LncRNA; Hotair; BMCS; Exosome; Rheumatoid arthritis; Matrix metalloprotease
资金
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A120152]
- National Research Foundation of Korea (NRF) - Korea government (MISP) [2011-0030130]
- National Research Foundation of Korea [2011-0030130] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.
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